RootBioTec HO is a potent basil hairy root extract that has been designed for users to regain fuller and denser hair. The product is based on a unique, sustainable technology for cosmetic actives – the so-called “hairy roots” technology.
5a reductase inhibition
RootBioTec HO inhibits 5a reductase and stimulates hair follicles 5a reductase II is the key target enzyme in the inhibition of hair loss. It is present in hair follicle cells and catalyses the reduction of testosterone into the more potent androgen dihydrotestosterone (DHT), which has two to three times greater androgenic receptors affinity.
RootBioTec HO demonstrated a clear concentration dependent inhibition of 5a reductase II with an IC value of 2.62 mg/mL. Finasteride, which is an approved 5a reductase inhibitor and synthetic drug for treating baldness in men, was used as a positive control.
Anti-Hair Loss Effects
The effect of RootBioTec HO against hair loss was evaluated on 19 woman and 2 men aged between 25 and 67 years who were suffering from mild to moderate hair loss (daily hair loss >100 strains). The volunteers applied a fluid containing 1% RootBioTec HO every evening for two months.
* 26% hair loss reduction at 1 month
* 31% hair reduction at 2 months
RootBioTec HO (oil-soluble)
INCI: Ocimum Basilicum Hairy Root Culture Extract (and) Helianthus Annuus (Sunflower) Seed Oil (and) Cocos Nucifera (Coconut) Oil
RootBioTec HW (water-based)
INCI: Ocimum Basilicum Hairy Root Culture Extract (and) Alcohol (and) Aqua