Carboxy-Methyl (CM)-Naringenin-Chalcone

Carboxy-Methyl (CM)-Naringenin-Chalcone is a single substance derived from the polyphenol naringenin chalcone, which naturally occurs in the peel of citrus fruits and tomato skin.

Mibelle Biochemistry developed a modified CM-Naringenin-Chalcone, a new compound with improved stability and water solubility.

Recent research reveals that an overproduction of the antimicrobial peptide cathelicidin LL37 in keratinocytes plays a major role in the development of the inflammatory skin disorder Rosacea. LL-37 induces the release of proinflammatorymediators, which lead to inflammatory reactions in the skin.

CM-Naringenin-Chalcone was shown to reduce the release of LL-37 induced pro-inflammatory cytokines in human keratinocytes. Furthermore, a placebo- controlled clinical study

confirmed a measurable reduction in capillary blood flow and a visible diminution of rosacea redness after 56 days of treatment.

• Visibly reduces redness in sensitive skin

• Protects and comforts stressed skin

• Down-regulates pro-inflammatory mediators

INCI: Tetrasodium Tetracarboxymethyl Naringeninchalcone, Aqua