Newsletter Issue 67	June 2015
PerfectionPeptide P7: The Cellular Defence Regulator from Mibelle Biochemistry PerfectionPeptide P7 is a new biologically active heptapeptide that stimulates the skin’s self-defence mechanisms against oxidative stress. Our cells respond to stress by activating the transcription factor Nrf2, the master switch in cellular self protection. Ageing slows this process. "This is the latest in a line of award-winning active ingredients from Mibelle Biochemistry. As always the efficacy data is second to none, leading to exciting anti-ageing opportunities." Kevin Cousins, Sales Director
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Background and significance of Nrf2 Oxidative stress is a key factor in premature ageing and cellular damage. Our cells respond to oxidative stress generated either internally or externally by activating the transcription factor Nrf2, which is a master switch in the cellular self protection system. However, ageing down regulates this natural process. In unstressed cells, Nrf2 activity is repressed by the Keap1 protein via a specific binding sequence. However, Mibelle Biochemistry has designed a heptapeptide that mimics this binding sequence and in doing so stimulates Nrf2 activity to enhance protection against reactive chemical species. >> Visit our YouTube channel to view a PerfectionPeptide P7 movie Efficacy data Cell culture assays and clinical studies have confirmed the capacity of PerfectionPeptide P7 to both boost Nrf2 activity and protect the skin from oxidative stress at cellular level: • DNA damage was significantly reduced. • UV-induced formation of sunburn cells and the depletion of Langerhans cells were also reduced. PerfectionPeptide P7 offers a unique strategy of ensuring protection against oxidative stress by activating Nrf2. In this way, the new anti-aging peptide actively prevents both extrinsic and chronological aging. PerfectionPeptide P7 won a BSB Innovation Prize at In-Cosmetics 2015, and Mibelle was presented with a lovely Oscar!  Summary of PerfectionPeptide benefits • Activates the skin’s self-protection capacity. • Fights both environmental and chronological ageing. • Protects DNA against oxidation. • Neutralises free radicals. • Empowers the skin’s own antioxidant capacity. INCI: Acetyl sh-Heptapeptide-1 (and) Hydrogenated Lecithin (and) Glycerin (and) Butyrospermum Parkii (Shea) Butter (and) Phenethyl Alcohol (and) Ethylhexylglycerin (and) Aqua >> Download PerfectionPeptide P7 brochure >> View a P7 video on our YouTube channel
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For further information about any of the products mentioned in this newsletter, please email us or contact your usual ProTec representative.
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